Biological Sciences Seminar

This is a past event.

PFT-Host Interactions: A Tale of Two Toxins with Ifrah Shahi ‘13, Graduate Student, Vilcek Institute of Biomedical Sciences, NYU Langone Health.

Pore forming toxins (PFTs) are commonly produced by pathogenic bacteria, and
understanding them is key to the development of virulence-targeted therapeutic strategies. I
am investigating mechanisms of action of two types of PFTs. The first PFT is the rhamnolipid
toxin produced by Streptococcus agalactiae; results from a CRISPR/Cas9 screen with the
toxin conclude that it does not require a non-essential receptor for binding to host cell
membranes. The second PFT I'm working with is a member of the Cholesterol Dependent
Cytolysin (CDCs) family, where I'm characterizing a novel humanCD59-dependent toxin
produced by the bacteria Streptococcus tigurinis.

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This event is being conducted over Zoom. As the host, Mount Holyoke College reserves the right to record this session and the event sponsors will give prior notification to event participants of any intention to do so. The recording feature for others is disabled so that no one else will be able to record this session through Zoom. At all times, no recording by any other means is permitted without prior written permission from the event sponsor or as an approved accommodation.

Tuesday, April 13 at 4:30pm to 6:00pm

Virtual Event
Event Type

Lectures & Presentations

Event Topic

Research, STEM

Event Audience

Students, Faculty, Staff

Biological Sciences
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