Steroid hormones control a wide range of processes, including the development of secondary sex characteristics, reproductive function, and dietary metabolism. Steroid hormones act in conjunction with receptor proteins to regulate the expression of target genes, ensuring that these genes are activated in the right tissues (tissue-specific gene induction) and at the right times (stage-specific gene induction).
The goal of our research is to answer one of the central questions of developmental biology - how can a single hormonal signal elicit different responses at different times and in different tissues during development? The fruit fly, Drosophila melanogaster, provides an ideal model system for unraveling the molecular mechanisms of steroid hormone action in the context of an intact animal. Drosophila undergoes a complete metamorphosis, transitioning from a larva to an adult fly. Metamorphosis is directed by a single steroid hormone called ecdysone.
By examining the molecular mechanisms whereby ecdysone regulates metamorphosis in the fly, we hope to gain a better understanding of how steroid hormones control developmental processes in general. Over the past three decades, our research group’s studies have provided strong evidence in support of the hypothesis that the nuclear receptor ßFTZ-F1 mediates the ecdysone-response of other genes, providing them with the competence to be induced in by the hormone in the correct cells at the appropriate developmental times. In directing the precise timing of target gene induction by ecdysone, ßFTZ-F1 ensures that developmental events occur in the right tissues at the correct time, and in the correct temporal order.
We hope that our studies will provide new insights into the molecular mechanisms of steroid hormone function in Drosophila, and in all animals.
This event is being conducted over Zoom. As the host, Mount Holyoke College reserves the right to record this session and the event sponsors will give prior notification to event participants of any intention to do so. The recording feature for others is disabled so that no one else will be able to record this session through Zoom. At all times, no recording by any other means is permitted without prior written permission from the event sponsor or as an approved accommodation.
Meeting ID: 986 7866 0116
One tap mobile
+16465588656,,98678660116#,,,,,,0#,,494710# US (New York)
+13017158592,,98678660116#,,,,,,0#,,494710# US (Germantown)
Dial by your location
+1 646 558 8656 US (New York)
+1 301 715 8592 US (Germantown)
+1 312 626 6799 US (Chicago)
+1 669 900 6833 US (San Jose)
+1 253 215 8782 US (Tacoma)
+1 346 248 7799 US (Houston)
Meeting ID: 986 7866 0116
Find your local number: https://mtholyoke.zoom.us/u/adKad8KuQC
Thursday, October 29 at 4:30pm to 6:00pmVirtual Event